Harley Quinn is back for Season 5 after a too-long break. And in the first episode, we’re headed to “The Big Apricot,” baby! Or more specifically Metropolis, which means new allies, new villains, and new members of the Harley Quinn voice cast.
We’ll get into all that in a second, but first a recap of the episode. And spoilers past this point. In the Season 5 premiere, Gotham City is besieged by giant rats, the Batfamily quit, and The Joker (former mayor) has been impeached. In the midst of that, Ivy and Harley are just trying to live their lives — impeded by the fact that the Gotham City Sirens, their team with Catwoman (and Oracle!!), dissolved after a mission to take a gem called The Heart of Darkness from Enchantress.
While everyone else from Riddler and Clock King to even Man-Bat seems to be doing great, Harlivy is stuck in a rut. But when they see a news report from Lois Lane about Metropolis, they decide to head to the city… Which is right across the bay from Gotham.
They head to a swanky party to celebrate the Superman museum, and once there discover a priceless relic is being revealed. So they knock out two Cirque de Supe performers in order to get their villain mojo back and steal the artifact, fighting off weird robots in the process. Turns out its the blanket Superman was wrapped in, but over the course of the heist the crowd, it seems, loves them.
So the next day they get invited to lunch at Tavern Over the Green by Lena Luthor, Lex’s sister, who is dating Bruce Wayne, and discover… She’s wearing the Heart of Darkness. Ivy attacks, they free villain Eclipso from the crystal, and immediately chop off his head.
By the time Superman arrives, it’s all over — and he’s bummed that Metropolis is so crime-free that nobody needs him anymore. Hey Supes, have you looked across the bay at Gotham? Anyway, Harley uses her therapy powers to convince Superman he needs to take a break, to which Superman loudly explains “And I think I’ll take that reporter Clark Kent with me,” leading to Harley thinking Superman is cheating on Lois with Clark, which is a Good Joke.
With Superman gone, Harley and Ivy move to Metropolis. Ivy is gonna help with the Metropolis Green Initiative, and Harley is gonna… Do Harley stuff. But turns out the weird robots were controlled by… Brainiac! After eliminating one of Ivy’s trees, e cut to the Coluan madman. “What a mess,” says Brainiac.
With that out of the way, let’s get to the Harley Quinn Episode 1 voice cast.
Harley Quinn Season 5, Episode 1 “The Big Apricot” Cast: Who’s Who In The Voice Cast?

Most of the main cast is back for Season 5, including Kaley Cuoco as Harley Quinn, and Lake Bell is back as Poison Ivy.
James Adomian, who voices the sublime Bane, does not appear as the back-breaker this episode. But he does do the voices of Clock King, Skeleton 1, and Eclipso. Diedrich Bader is also back as Bruce Wayne after voicing Batman (wait a second!!) in previous seasons, as well as Automaton Sentry.
Briana Cuoco is also back — briefly — as Oracle, Jim Rash returns as The Riddler (and Waiter), and James Wolk returns as Superman, a role he played in previous seasons as well. Cherise Boothe is also back as Catwoman in this episode.
The big addition is Stephen Fry as Brainiac. One-half of the comedy duo Fry & Laurie, the actor, author, and radio presenter has been around for decades in everything from Blackadder to, most recently, playing another robot in Skeleton Crew.
The other big addition? Aisha Tyler plays Lena Luthor, and you definitely know her from Criminal Minds, Archer, or perhaps her stint hosting The Talk.
Other than Fry and Tyler you’ve got Natalie Morales as the voice of Lois Lane, and you likely know her from The Middleman, Grey’s Anatomy, or Parks & Recreation, among many other roles.
Tisha Campbell plays Tawny and Manager, and she’s played various voice roles on Harley Quinn in the past. She’s also previously appeared in the House Party movies, and Little Shop of Horrors. And Katie Rich, who was co-executive producer on Kite Man: Hell Yeah! and is EP of Harley Quinn does the voices of Enchantress and Child.
Harley Quinn Season 5, Episode 1 Cast List:

Here’s a full cast list from Harley Quinn Season 5, Episode 1, “The Big Apricot” if you prefer to read it in list style instead of written out, as above:
Harley Quinn…Kaley Cuoco
Poison Ivy…Lake Bell
Clock King, Skeleton 1, Eclipso…James Adomian
Bruce Wayne, Automaton Sentry…Diedrich Bader
Oracle…Brianna Cuoco
Brainiac…Stephen Fry
Lois Lane…Natalie Morales
Lena Luthor…Aisha Tyler
The Riddler, Waiter…Jim Rash
Catwoman…Cherise Boothe
Tawny, Manager…Tisha Campbell
Enchantress, Child…Katie Rich
Superman…James Wolk
Where To Watch Harley Quinn:
Harley Quinn Season 5 Premiere Dates And Episode Guide:
The first episode of Harley Quinn Season 5 premieres Thursday, January 16 at 3 am ET / Midnight PT on Max. One episode a week premieres after that, leading to the season finale on March 20, 2025.
Here’s the full list of episodes in Harley Quinn Season 5, with premiere dates:
- Thursday, January 16, 2025: Harley Quinn, Season 5, Episode 1: “The Big Apricot”
- Thursday, January 23, 2025: Harley Quinn, Season 5, Episode 2
- Thursday, January 30, 2025: Harley Quinn, Season 5, Episode 3
- Thursday, February 6, 2025: Harley Quinn, Season 5, Episode 4
- Thursday, February 13, 2025: Harley Quinn, Season 5, Episode 5
- Thursday, February 20, 2025: Harley Quinn, Season 5, Episode 6
- Thursday, February 27, 2025: Harley Quinn, Season 5, Episode 7
- Thursday, March 6, 2025: Harley Quinn, Season 5, Episode 8
- Thursday, March 13, 2025: Harley Quinn, Season 5, Episode 9
- Thursday, March 20, 2025: Harley Quinn, Season 5, Episode 10 *Season Finale*
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